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Actually, many researchers agree that leptins main role is to signal starvation (via falling leptin levels) and consequently produce appropriate behavioral and metabolic responses that increase the chances of survival 27, 28

But as your cat loses kidney function, it becomes increasingly difficult to remove these waste products

And drinking a gallon of water on the couch is not going to fix it

You're ordering initial screening labs (one category of data), and the treatment plan is low risk (diagnostic workup only, no treatment initiated)

When activated, it switches on genes for mitochondrial biogenesis, oxidative phosphorylation, the TCA cycle, and fatty acid -oxidation