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Depletion of GSH and therapeutic implications The depletion of GSH levels has been demonstrated in aging and multiple chronic degenerative diseases, including neurodegenerative, cardiovascular, pulmonary, immune disorders and cancers ( For this reason, many studies have been conducted on the best methods to increase intracellular and intramitochondrial levels of GSH

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doi:10.1042/0264-6021:3600001

Studies consistently show altered MGBA composition in AD patients, suggesting a possible role in disease onset and progression, as shown in Table 1

doi: 10.1053/j.gastro.2016.01.032 48

N-acetylcysteine reduces oxidative stress in sickle cell patients