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Toll-like receptor 4 on islet Cells senses expression changes in high-mobility group box 1 and contributes to the initiation of type 1 diabetes

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

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Via their stored and newly synthesized neuroactive mediators (including IL-6 and IL-1), mast cells can promote microglial and astrocytic reactivity (Skaper et al., 2014