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doi: 10.1017/cjn.2017.284 48

M., Burke T

As such, the results of this largest, latest RCT did not demonstrate a beneficial effect of RTX on pSS

According to this study (137), it has been shown that in UC, the activation of the iNOS/COX-2/5-LOX loop and increased levels of their end products, such as NO, prostaglandin E2 (PGE2), and leukotriene B 4 (LTB 4), which lead to the overproduction of free radicals and the impairment of the antioxidative system