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NMDA antagonists also show promise in other serious psychiatric disorders such as obsessive-compulsive disorder

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Protocol [1] Posterior cortex, hippocampus, striatum and liver supernatants of 30-day-old rats are pre-incubated for 30 min at 30C in the presence of L-Tyrosine (Tyr) at final concentrations ranging from 0.1, 1.0, 2.0 or 4.0 mM, and the activities of citrate synthase, malate dehydrogenase and respiratory chain complexes I, II, IIIII and IV are evaluated [1]

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Interestingly, the chemotherapeutic agent 5-fluorouracil, at relatively high concentrations, has also been demonstrated to suppress the expression of CBS