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[DOI] [PMC free article] [PubMed] [Google Scholar] 54.Cerk IK, Salzburger B, Boeszoermenyi A, Heier C, Pillip C, Romauch M, et al

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Because IGFBP-3 also carries IGF-1, when IGF-1 is administered on its own, the carrier IGFBP-3 saturates with IGF-1 displacing IGF-2 and thus augments its free circulating concentration

in the 100 mg dose present here, serious GI effects are uncommon, but mild nausea or stomach discomfort could occur in sensitive patients

They are therefore not deemed essential as such