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Its anti-inflammatory effects are mediated by its ability to suppress the expression and release of pro-inflammatory cytokines, such as Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-), in various cell culture models

Of course we cant know if this imposed reduced frequency had any impact however the word pernicious springs to mind

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Vitamin B12 Forms in the Body In the body, absorbed B12 works as a coenzyme (further info: Vitamin B12 Benefits), which supports the functions of a multitude of important enzymes