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Tumor antigen-targeted, monoclonal antibody-based immunotherapy: clinical response, cellular immunity, and immunoescape

MDHA is either directly reduced back to AsA by MDHAR or undergoes non-enzymatic disproportionation to AsA and dehydroascorbate (DHA)

Lower BMI thresholds may apply for certain ethnic groups

These associations further support the hypothesis of genetic susceptibility as a predisposing factor for PBC

Red-flag symptoms such as severe abdominal pain, persistent vomiting, or jaundice require immediate cessation and urgent medical attention

Where a claim rests on retracted work, that status is stated alongside it