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Urolithin A ameliorates athletic ability and intestinal microbiota in sleep deprivation from the perspective of the gut-muscle axis

Kim ST, Choi M, Bae SJ, Kim JS

24 hours) reduces LPS (2.5 g/ml)-induced TNF- and IL-6 by 50% and 46% combined with carbachol (10 M), respectively and does not cause any significant reduction in pro-inflammatory cytokines [3]

[PubMed: 16904799] (Evaluation of the safety of oral ALA in rats who exhibited no evidence of toxicity except at the highest doses tested [121 mg/kg], which was associated with minor ALT elevations in males and slight changes in liver histology including small droplet fat in periportal regions, but without frank hepatocyte necrosis or inflammation)

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