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Yes, this combination has been extensively studied in clinical trials under the name CagriSema

This led to the organization of the actin cytoskeleton, elevated the expression of integrin beta 1, and restored collagen contraction [12]

Downstream signaling involves PI3K/AKT, MAPK/ERK, and PLC- pathways, which are well-characterized drivers of synaptogenesis, dendritic spine maturation, and neuronal survival