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Mitochondria regulation in ferroptosis

When winter comes and sun exposure drops, they fade naturally

However, silencing the expression of endogenous ATF4 using a small interfering RNA (siATF4) significantly increased the cell proliferation inhibition rate (Figure 6A)

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By modulating the activity of DDR-related proteins, such as YTHDC1 [198], RAD18 [199], RRM1 [200] and HMGB1 [201], O-GlcNAcylation can regulate the DDR and affect genome stability, representing a potential therapeutic target for cancer therapy [202]