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Oxidative stress and antioxidant therapy in cystic fibrosis

The administration of a single oral dose of 1,3-dinitrobenzene caused central nervous system toxicity (ataxia) in GF rats but not in conventional rats, whereas repeated oral dosing with 1,3-dinitrobenzene was required to cause ataxia in conventional rats

CBP80-promoted mRNP rearrangements during the pioneer round of translation, nonsense-mediated mRNA decay, and thereafter

nitric oxide and peroxynitrite are included in RNS

Upon chronic exposure, most of these metals accumulate in the body throughout human life and their biological effect contributes to shorten the natural lifespan of organs such as the kidney and ultimately determine their early failure [1]

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