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Importantly, only unbound drugs can pass the cellular membrane, undergo biotransformation (in the case of prodrugs), and interact with a target

Common supplemental forms include: L-arginine HCL : The standard hydrochloride form L-arginine alpha-ketoglutarate (AAKG) : Popular in sports supplements Arginine nitrate : A newer form combining arginine with nitrate for potentially enhanced effects Beyond its role in nitric oxide production, L-arginine participates in protein synthesis, ammonia detoxification, and hormone secretion