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Sun K, Li C, Liao S, Yao X, Ouyang Y, Liu Y, et al

Together, these findings provide compelling evidence that oxidative stress plays a critical role in the pathophysiology of depression and may represent both a biomarker of disease severity and a potential target for therapeutic intervention through modulation of antioxidant defenses (3537)

The symptoms do not identify a specific toxin, but they may justify a targeted review of environmental exposure, medications, alcohol, gut dysfunction, copperzinc balance, methylation and organ clearance