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Its approval was supported by data from the Phase III CAHtalyst study, which demonstrated that Crenessity significantly lowered androstenedione concentrations in both adult and pediatric patients, allowing them to taper glucocorticoid doses without affecting treatment efficacy

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Some intrinsic and extrinsic factors related to increased glycolysis described below are associated with chemoresistance mechanisms in various tumor models, including ALs (Supplementary Table S1)

Although these findings were obtained in other experimental models than CRC, they suggest that H

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