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Figure 3 Deletion of sucE in glutarate producer GluA did not negatively affect glutarate production, however, growth was slowed (0.12 0.00 h 1 for GluA vs

The optic nerve lesions in both mouse models lacked some common features of PA but displayed some morphological and pathological features reminiscent of the NF1-associated human tumors (78)

Additionally, reduced expression of glial fibrillary acidic protein (GFAP) and lonized calcium-binding adapter molecule 1 (Iba-1) in glial cells was observed, indicating decreased inflammatory responses

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We also used cell-permeable 2-OG (dimethyl 2-OG, DM-2OG), as a control for 2-OG accumulation driving 2-HG formation, as excess 2-OG has been previously shown to drive PHD inhibition via L-2-HG 22,24