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The rarity of this case, as well as its diagnostic difficulty and severity, demonstrates the importance of such reports, so that the disease becomes more widely known among healthcare professionals, especially dermatologists who conduct ongoing follow-up of patients with NF1, those primarily affected by the tumor

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The pharmacokinetics of exosomes in the complex human spinal cord environment remains a major obstacle in clinical trial design

Heijtz RD, Wang S, Anuar F et al (2011) Normal gut microbiota modulates brain development and behavior

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It may be viewed as a major pathological endpoint at which aberrant signaling across multiple omics layersincluding genetics, epigenetics, transcription, proteomics, metabolomics, immunity, and the microbiomeconverges (13)