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The 12-week mark aligns with what clinical GHK-Cu skin trials use as their primary endpoint, and the published results from those trials reflect what researchers running systematic protocols report: clear, documented improvement in skin architecture

doi: 10.3389/fnut.2025.1663327 Received 10 July 2025 Revised 28 October 2025 Accepted 07 November 2025 Published 19 November 2025 Volume 12 - 2025 Edited by Jing Gao, National Engineering Research Center for Oil Tea, China Reviewed by Cheng-Ting Zi, Yunnan Agricultural University, China Maria Velez, Centro de Investigacin y Extensin Forestal Andino Patagnico (CIEFAP), Argentina Updates Copyright 2025 Li, Zhao, Li, Li, Zhao, Cui, Li, Guo and Bian

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