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Finally, post-translational hydroxylation of eukaryotic release factor 1 (eRF1) by oxygen-sensitiveJMJD4 (Jumonji domain-containing 4) (Box 2) is required for efficient translation termination rates during normoxia 48 , and during hypoxia, decreased eRF1 hydroxylation leads to inefficient termination (Figure 2)

Gnanasammandhan MK, Idris NM, Bansal A, Huang K, Zhang Y

Your care plan may also include pelvic floor therapy, lifestyle changes, sexual counseling, partner communication, oral medication, a vacuum device, or other approaches based on your medical history

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The failure of these mitochondrial complexes in brain tissue is also expected to increase ROS production leading to further localized cellular damage

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