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10.1007/pl00000319 55 Sanchez-MendozaM

doi: 10.1378/chest.101.4.1160

Immune checkpoint inhibitors and ferroptosis inducers have been shown to work in concert in preclinical models to enhance anti-tumor immunity and cancer cell death (Cai et al

& Guan, H

This method enables the detection of cell subsets potentially undergoing ferroptosis, understanding the state of cells, and treating the symptoms

Similarly, MRTX849 treatment decreased intratumoural immunosuppressive myeloid-derived suppressor cells and M2-polarised macrophages and increased immune-promoting M1-polarised macrophages, dendritic cells, and CD4 + and NKT cells in KRAS (G12C) tumours by altering the expression of tumour RNA and protein implicated in the presentation of tumour antigens or mediating an immunosuppressive TME 204