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The phagophore, and hence autophagosome formation requires the generation of an initiation complex named Unc51-like kinase 1 (ULK1) complex composed of ULK1, Atg13, FIP200, and Atg101 (Yang et al., 2015

IHC, immunohistochemistry

The study found that metastatic cells can adopt different strategies to protect themselves against ferroptosis depending on the location they are spreading to

N = 91 with neurotypical children) between 6 and 18 years of age

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These results indicate that the increase in apoptosis is a direct result of loss of UVRAG expression rather than a secondary result of autophagy inhibition causing a shift to the apoptosis pathway