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Class III, which includes the NAD+-dependent sirtuins (SIRTs)

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c) Obtaining objective evidence of mast cell activation Obtaining objective evidence of mast cell activation, through measurement of serum tryptase or urine metabolites of mast cell mediators in relation to episodic symptoms, is required for confirming a diagnosis of MCAS [3]

doi:10.1093/annonc/mdv580 Kong, B.Y., Micklethwaite, K.P., Swaminathan, S., Kefford, R.F., & Carlino, M.S