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The inducible HMOX isoform (HMOX1, OMIM*141250), a member of the heat-shock protein HSP32 family, is activated by a number of oxidative stress-provoking stimuli

In recent years the emergence and spread of artemisinin resistance in South-East Asia, sub-Saharan Africa, India, South America and Papua New Guinea has contributed to treatment failures 1

Phospholipase A2, reactive oxygen species, lipid peroxidation in cerebral ischemia

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Cancer Certain GST variants have been associated with an increased risk of cancer development due to their potential impairment of detoxification processes for carcinogens and reactive oxygen species, thereby promoting DNA damage and oncogenesis