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doi: 10.1038/nrm1155 188 PintonPGiorgiCSivieroRZecchiniERizzutoR

When the body experiences chronic stress, the adrenal glands work overtime to produce cortisol, the primary stress hormone

"The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex"

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In the mature DPP1 molecule, the exclusion domain binds the catalytic domain through non-covalent interactions and restricts substrate access to regions upstream of the S2 subsite via steric hindrance, determining DPP1s unique dipeptidyl peptidase activity ( The DPP1 active site structure reflects the molecular basis for its broad substrate specificity