northern green frog rana clamitans melanota (Rana melanota) | Juvenile fro… Northern green frog lithobates clamitans

Ataxia-telangiectasia mutated (ATM) protein kinase is activated by DNA double strand breaks (DSBs) to initiate DNA damage response

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Low baseline levels of cysteine in blood and in CD4, CD8 T lymphocytes, B-cells, and monocytes were returned to normal after a single oral dose of N-acetylcysteine (30 mg/kg body weight) (Figure 2)

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Subsequent studies show NLRP3 inflammasome activation exacerbates IR and damages islet cells, accelerating T2DM progression [70, 71]