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The mechanism includes hypoxia and regulation of IK-ATP (67-69)

Cell reagents Cells and organoids were treated with the following compounds as indicated: 5FU (Abcam, ab142387-5g

Humoral immune responses to nonlipidated spirochetal proteins are more likely to be T cell dependent

Understanding that high B12 serves primarily as a biochemical marker prompting further investigation is essential for appropriate clinical management and identifying potentially significant underlying pathology

Contraindications: This product is contraindicated in patients with a known hypersensitivity to any of the active ingredients or excipients

Patient characteristics are provided in Supplemental Table 1