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Further studies in Per2Luc knock-in mice revealed that chronic light-dark disruption elevated pro-inflammatory cytokines (e.g., IL1, IL6, GM-CSF) and impaired host resilience to endotoxin challenge 126

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[31] Gysin, R., Kraftsik, R., Sandell, J., Bovet, P., Chappuis, C., Conus, P

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[51] It binds to acetaldehyde to form the low-toxicity heterocycle methylthioproline