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Notably, all these studies are preclinical and involve experimental animal models, encompassing diverse pathways and targets

Skeletal muscle served as a post-mitotic tissue with limited roles in each of these systems

Silybin showed higher cytotoxic, antiproliferative, and anti-inflammatory activities in the CaCo cancer cell line while retaining viability and proliferation in normal intestinal IPEC-1 cells

[Google Scholar] 133.Valiante V, Baldin C, Hortschansky P, Jain R, Thywien A, Straburger M, et al

Thus, poorer dynamics of phylloquinone and MK4 in the lipid bilayer owing to the lengthy side chains may give rise to their localization within the lipid membrane, suppressing their autoxidation and the consumption of reducing equivalents from NADH or NADPH (Extended Data Fig