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however, no case of ECL cell carcinoids, dysplasia, or neoplasia has been found in these patients [see Nonclinical Toxicology (13.1)] In over 1,000 patients treated with oral esomeprazole (10 mg, 20 mg or 40 mg/day) for up to 12 months, the prevalence of ECL cell hyperplasia increased with time and dose

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PubMed PMID: 16310594

During the initial stage of treatment, INR is checked daily

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Inactivation of muscle insulin and IGF-I receptors and insulin responsiveness