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Safety of IGFs Clinical Studies in Patients with AD Treatments aimed at increasing circulating IGF-1 levels have demonstrated favorable safety profiles in multiple clinical trials involving patients with AD or MCI [16,17,18, 232]

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Its extreme local potency, coupled with the systemic risks inherent to IGF-1 (such as potential tumor acceleration and long-term changes in glucose regulation), means its use should be strictly confined to controlled research settings with rigorous safety monitoring

Another derivative, propionyl- L -carnitine, has been linked to enhanced cardiovascular health and exercise performance, while its effects on gut microbiota and TMAO formation are less well understood [5052]