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Additionally, 1,8-diMQ and 5-amino-1MQ showed little inhibition of COMT at maximal tested concentrations of 200 M (20% inhibition) and 600 M (10% inhibition), respectively, although no clear trend of concentration-dependent inhibition was observed

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Biochemical Investigations The levels of LPO and GSH, as well as GST activity, were measured in the liver homogenate using the following methods of Preuss et al

Constipation at higher doses Constipation becomes more common as your dose increases, particularly above 1.0 mg

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Blood tests can determine if you have a B12 deficiency and help your healthcare provider suggest the best treatment options