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Oral versus intramuscular cobalamin to treat cobalamin deficiency: noninferiority randomised controlled trial, pragmatic and multicenter in the primary healthcare setting (OB12 project)

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Administer vitamin B12 1 mg intramuscularly 1 week prior to the first dose of PEMFEXY and every 3 cycles thereafter

Gonzlez-Guerra JL, Castilla-Cortazar I, Aguirre GA, Muoz U, Martn-Estal I, vila-Gallego E, Granado M, Puche JE, Garca-Villaln A (2017a) The sole partial insulin-like growth factor (IGF-1) deficiency reduces heart contractibility, angiotensin II sensibility, and alters gene expression of structural and functional cardiac proteins Gonzlez-Guerra JL, Castilla-Cortazar I, Aguirre GA et al (2017b) Partial IGF-1 deficiency is sufficient to reduce heart contractibility, angiotensin II sensibility, and alter gene expression of structural and functional cardiac proteins

Due to its targeted interaction with NNMT, 5-Amino-1MQ serves as a valuable research tool for studying metabolic enzyme activity and peptide-independent regulatory mechanisms