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Fragmented oxidized mtDNA enters the cytosol where it activates NLRP3 inflammasome and generates the production of IL-1, IL-18, and cyclic GMP-AMP synthase-STING, inducing type I interferons and interferon-stimulated genes (Orekhov et al., 2023)

At physiological concentration ([Hb]: 1214 mg/dL), hemopure, a hemoglobin-based oxygen carrier (HBOC-201), can deliver more oxygen than water (98% vs 2%)

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This method ensures rapid absorption, allowing the body to utilize the vitamin more efficiently than oral supplements

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The results highlight the efficacy of off-the-shelf, single-neoantigen mRNA vaccines in delivering clinical benefits to the late-stage cancer patients, especially when aligned with high-frequency HLA subtypes such as HLA-A*11:01, indicating a viable approach for expanding immune treatment options [13]