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Direct measurement of the binding proteins is more informative when available." How should suspected biotin or heterophile-antibody interference change interpretation of an immunoassay-based B12 result

15 The biologic consequences of the activation and degranulation of mast cells in the rheumatoid synovial tissue are complex and despite their ability to mediate inflammation was neglected for years, the mast cell and its products are now recognized as novel targets for therapy of rheumatoid arthritis

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3.5 Meta-analysis The included studies showed substantial heterogeneity (I 2 = 99.6%, p 0.05), supporting the conclusion of comparable efficacy and the lack of a clear doseresponse relationship

It is generally believed that activation of mTORC1 by specific amino acids, notably leucine, starts with its recruitment to the lysosomal membrane by GTPases called Rags, which are concentrated there as heterodimers consisting of RagA or RagB combined with RagC or RagD

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