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suggests that multiple amino acid substitutions are introduced to support the peptides stability against enzymatic degradation potentially: (1) Position 2 (Alanine D-Alanine): Introduces a D-form amino acid, which is less susceptible to standard enzymatic breakdown

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It was developed in the 2000s via epitope mapping of antibodies to the endogenous neurotrophic factor CNTF, which helped locate the most active regions of the CNTF sequence [16]