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To suppress the generation of H 2 O 2 various antioxidants such as catalase reacts with them and neutralize their effect

acknowledges support from the National Institutes of Health (NIH) (P50CA272218) and the Melanoma Research Foundation

SS-31 research is therefore most relevant when the study question involves mitochondrial dysfunction, impaired ATP output, oxidative stress, cardiomyopathy, skeletal-muscle fatigue, primary mitochondrial disease, or age-related mitochondrial decline

Glutathione protects thiol protein groups from oxidation and is involved in cellular detoxification for maintenance of the cell environment

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Only two residues that interact ionically with NADP(H) in the bovine catalase (Asp212 and His304) differ in HPII (Glu270 and Glu362), but it has been proven that their mutation to the bovine sequence does not promote nucleotide binding [4]