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TFAM binds to mtDNA and forms a nuclear-like structure, thereby protecting mtDNA from the adverse effects of A toxicity and oxidative stress, inhibiting the vicious cycle of neuronal mitochondrial dysfunction, and thus improving the pathophysiology of Alzheimers disease (Oka et al., 2016)

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When B12 is genuinely low, hair changes are well documented increased shedding, slower growth, reduced hair quality

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