Biochemistry 34:656665
While many peptides are showing incredible promise in clinical research, most are not yet FDA-approved for general use
ZD and dysregulation have been implicated in synaptic dysfunction and impaired learning and memory
64% of infants receive acetaminophen within 48 hours after vaccination Acetaminophen used 2.6x more frequently than ibuprofen Why newborns are uniquely vulnerable: Glucuronidation severely underdeveloped (primary adult pathway barely functions) Sulfation predominates but easily saturated Limited glutathione reserves When sulfation is saturated, more acetaminophen is forced through the oxidative pathway to NAPQI The compounding effect: Before birth: Mother has compromised glutathione takes acetaminophen fetal brain exposed to NAPQI fetus cannot effectively detoxify After birth: Baby loses maternal protection immature detoxification receives acetaminophen at 2, 4, 6, 12 months with vaccinations cumulative burden may exceed threshold The math: 200,000+ pregnancies per year involve acetaminophen use in women with compromised glutathione Of those, 64% of infants receive acetaminophen after first vaccination That's approximately 128,000 infants per year with vulnerable prenatal exposure AND postnatal acetaminophen 100,000 children diagnosed with neurodevelopmental disorders annually This isn't about vaccines causing neurodevelopmental disorders
long-term safety unknown Glucagon Glucagon, a peptide, produced by A cells of the pancreatic islets of Langerhans Glucagon is arrived from a large precursor peptide (one intermediate: glicentin, 69-amino acid peptide) Rapidly inactivated in plasma (degraded also at hepatic, renal, and tissue receptor sites) Enteroglucagons: Glicentin immunoreactivity: cells of the small intestine, pancreatic A cells, pancreatic effluent-- glucagon-like peptides Glucagon: Pharmacological activity Metabolic: glucagon interacts with specific, hepatic receptors G protein activation, increase in adenylyl cyclase activity, increases cAMP production Increased catabolism of stored glycogen, increased gluconeogenesis, increased ketogenesis Pharmacological consequences: increased blood glucose, decreased hepatic glycogen insulin released from normal pancreatic B cells catecholamines from pheochromocytoma calcitonin from medullary carcinoma Cardiovascular Effects: positive inotropic action (increased myocardial contractility) positive chronotropic (increased heart rate) these effects mediated by cAMP Smooth Muscle Effects: (large doses): intestinal smooth muscle relaxation Management of Severe Hypoglycemic States emergency treatment in insulin-dependent unconscious patients in which intravenous glucose cannot be administered (a conscious patient would be treated by drinking orange juice or other high sugar content foods) Glucagon is available for parenteral use
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