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For instance, genes which are important for ferroptosis resistance [e.g., ACSL3 , ferritin heavy chain ( FTH1 ), GPX4 , GSS and voltage-dependent anion channel 2 and 3 ( VDAC2/3 )] are downregulated in an early stage of AD pathology but upregulated at later AD stage

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The results were compelling: the leucovorin group showed significantly greater gains in language scores compared to placebo, with a medium-to-large effect size (Cohens d 0.70)