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As the global population ages, the prevalence of AD is rapidly increasing, imposing a significant burden on patients, caregivers, and healthcare systems

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The involvement of NIK in RA pathogenesis is also suggested by the finding that NIK is highly expressed in the ECs of inflamed RA synovial tissue and promotes pathological angiogenesis in preclinical models of arthritis [128, 129]

Also, a significant increase in the mean percentage area was observed in the hyperthyroid group was observed compared with the control and treated groups (Fig

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