Average body weight reduction was 11%
2018 Nov;62(22):e1800411
inject PRP around the nerve to separate adhesions and deliver growth factors Aftercare: brief rest followed by gentle hip mobility exercises and physical therapy Evidence Summary Case reports describe successful PRP hydrodissection of the LFCN with significant symptom relief Animal models demonstrate accelerated axonal growth and increased myelin thickness with PRP application Systematic reviews highlight PRPs safety profile and call for controlled trials in entrapment neuropathies Advantages & Considerations Advantages Autologous and low risk of allergy Minimally invasive outpatient procedure Combines mechanical hydrodissection with regenerative biology Considerations Variability in PRP formulations (platelet concentration, leukocyte content) Cost and insurance coverage may vary Need for high-quality, long-term clinical trials Future Directions Standardize PRP preparation protocols (platelet counts, leukocyte levels) Conduct comparative trials versus corticosteroids or dextrose prolotherapy Evaluate long-term outcomes through imaging and electrophysiology Take-Home Messages Meralgia paresthetica is a sensory neuropathy caused by compression of the LFCN, leading to outer-thigh burning, tingling, or numbness Most cases improve with lifestyle changes, medications, and nerve blocks PRP hydrodissection offers a novel regenerative approach for refractory cases Rigorous clinical trials are needed before PRP becomes a standard treatment
Absorption of inhaled steroids is unlikely to affect breastfed infants
We like to use a vitamin B12 that is combined and balanced with an ample amount of folic acid, which should always be included with vitamin B12 to make sure that a folic acid deficiency is not masked
Men without baseline labs or medical supervision should not begin peptide therapy, because dosing and safety depend on health history, hormone levels, metabolic markers, and treatment goals
