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TB-500 may inhibit apoptosis in corneal epithelial cells by obstructing caspases and limiting the release of the pro-apoptotic protein bcl-2 from mitochondria

Systemic factors include aging, sex hormones, stress, malnutrition, obesity, habits (like alcoholism and smoking), chronic medical conditions (including diabetes, endocrine and vascular disorders), medications such as corticosteroids and immunosuppressants, immunocompromised conditions including cancer, radiation therapy, AIDS