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Evidence for this comes from a study by Marino et al., which found that modulation of the IL-6 pathway attenuated mechanical hyperalgesia and thermal hypersensitivity in a reserpine-induced rat model of fibromyalgia (Zhou et al., 2016a)

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Yet, even in an era of unprecedented scientific collaboration, many of the studies reviewed here exhibit substantial variability in experimental design and treatment approacheshindering meaningful comparisons and challenging the reproducibility of results

Moreover, HSCs activation need to be resolved soon after acute stress to protect their integrity and prevent their exhaustion

It reduces melanin production and promotes a brighter, more even complexion