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It has been shown that -pinene, zolpidem, and flumazenil bind to BZD binding site between 1 and 2-subunits in extracellular domain of GABA A receptor through the molecular modeling, encompassing theoretical and computational methods to model or mimic the behavior of the molecules [33]

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In earlier studies, methods such as UVvisible spectrophotometry, neutron activation analyses, and graphite furnace atomic absorption spectrometry were commonly used