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331 Additionally, the matricellular protein SPARC, a novel tumor-derived vascular permeability factor, disrupts the endothelial barrier through vascular cell adhesion molecule 1 and p38 MAPK-mediated signaling, thereby promoting the metastatic competence of tumor cells

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AHK-Cu is water-soluble, pH-sensitive, and requires a carrier formulation that works with the compound rather than against it