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IK, EF, KK, and RV prepared, and NA performed critical reading and revision of the manuscript

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Therefore, cerebral serotonin is synthetized in the brain, where it plays a major role in mood regulation and, after transformation in melatonin, in sleep regulation (155, 156), as summarized in Figure 1

Nevertheless, several formidable challenges persist in translating this paradigmatic understanding into clinically validated therapeutic interventions

Trough samples at Weeks 13 and 39 were taken on Day 7

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