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Nei et al, 2013

Post-Injection Guidance Your provider discusses any follow-up recommendations, including the suggested frequency for ongoing injections based on your individual needs and goals

Multi-dose protocols maintain IGF-1 above baseline for 28 days in healthy adults

The typical loading phase involves 2-2.5 mg twice weekly for 4-6 weeks, allowing tissue concentrations to reach therapeutic levels

Interstitial cystitis in the UK: results of a questionnaire survey of members of the Interstitial Cystitis Support Group

This is not proven for retatrutide specifically, but the principle is well-established for other peptides of comparable size