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Lastly, PFK15 treatment had no impact on circulating CD4 + T cell frequencies in the peripheral blood, however reduced CD4 + T cell percentages were observed in the spleens of treated animals, indicating reduced expansion of PFK15 treated T cells ( Figure 3J )

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These effects were mediated through the modulation of key molecular markers, including Bax, caspase-3, Beclin 1, LC3 I/II, mitochondrial membrane potential, Bcl-2, p-p65, p-IKK/, and p-IB [114]