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Finally, the review will address the current challenges in the field, including issues related to biocompatibility, scalability, and regulatory considerations, while discussing future perspectives such as the integration of advanced technologies like stimuli-responsive systems and theranostic approaches

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However, a limitation of using lasparaginase for targeting glutamine is the potential development of immunosuppression due to low glutamine levels required for the proliferation of immune cells [343]

Recent literature suggests that 68% of Chinese cancer patients treated with Crizotinib experience elevated serum aminotransferases, with a higher prevalence observed in Chinese patients compared to non-Chinese patients [3, 4]

In contrast, GABA exhibits both excitatory and inhibitory actions in insects, mediating muscle activation at synapses between nerves and muscle cells, and also the stimulation of certain glands