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thaliana , GRXs are represented by six class I, four class II, and two class IV isoforms, while class III GRXs (also referred to as CC-type GRX or ROXY proteins) have largely expanded and comprise 21 members with multiple functions

Figure 5 shows the chemical structures of Erastin and these representative analogs/derivatives

Summary Keywords acute lymphoblastic leukemia, methotrexate, glutathione, metabolomics, drug resistance, arsenic trioxide, thioredoxin reductase Citation Canevarolo RR, Melo CPS, Cury NM, Artico LL, Corra JR, Lau YT, Mariano SS, Sudalagunta PR, Brandalise SR, Zeri ACM and Yunes JA (2022) Glutathione levels are associated with methotrexate resistance in acute lymphoblastic leukemia cell lines

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